diff --git a/.github/actions/run-integration-test/action.yml b/.github/actions/run-integration-test/action.yml
new file mode 100644
index 0000000000..07f63b39a4
--- /dev/null
+++ b/.github/actions/run-integration-test/action.yml
@@ -0,0 +1,45 @@
+name: "Run Integration Test"
+description: "Run integration tests with retry on infra failures"
+
+inputs:
+  make-args:
+    description: "Extra arguments to pass to make (e.g. FIREFOX_CHANNEL=beta)"
+    default: ""
+  retries:
+    description: "Number of retry attempts after the first failure"
+    default: "1"
+  artifact-name:
+    description: "Name for the uploaded test report artifact"
+    required: true
+
+runs:
+  using: composite
+  steps:
+    - name: Run integration tests
+      shell: bash
+      env:
+        BUILDKIT_PROGRESS: plain
+        COMPOSE_ANSI: never
+      run: |
+        cp .env.integration-tests .env
+        attempts=$(( ${{ inputs.retries }} + 1 ))
+        for attempt in $(seq 1 "$attempts"); do
+          echo "::group::Attempt $attempt of $attempts"
+          if make refresh SKIP_DUMMY=1 ${{ inputs.make-args }} up_prod_detached integration_test_nimbus_desktop PYTEST_ARGS="$PYTEST_ARGS"; then
+            echo "::endgroup::"
+            exit 0
+          fi
+          echo "::endgroup::"
+          if [ "$attempt" -eq "$attempts" ]; then
+            echo "::error::All $attempts attempts failed"
+            exit 1
+          fi
+          echo "::warning::Attempt $attempt failed, retrying..."
+        done
+
+    - name: Upload test report
+      if: always()
+      uses: actions/upload-artifact@v4
+      with:
+        name: ${{ inputs.artifact-name }}
+        path: experimenter/tests/integration/test-reports/report.htm
diff --git a/.github/workflows/integration-desktop-enrollment.yml b/.github/workflows/integration-desktop-enrollment.yml
new file mode 100644
index 0000000000..5a9bc4821d
--- /dev/null
+++ b/.github/workflows/integration-desktop-enrollment.yml
@@ -0,0 +1,46 @@
+name: Desktop Enrollment Integration Tests
+
+on:
+  push:
+    branches:
+      - main
+    paths:
+      - "experimenter/**"
+      - "application-services/**"
+      - ".github/actions/run-integration-test/**"
+      - ".github/workflows/integration-desktop-enrollment.yml"
+  pull_request:
+    paths:
+      - "experimenter/**"
+      - "application-services/**"
+      - ".github/actions/run-integration-test/**"
+      - ".github/workflows/integration-desktop-enrollment.yml"
+  merge_group:
+    types: [checks_requested]
+
+jobs:
+  test:
+    strategy:
+      fail-fast: false
+      matrix:
+        split: [0, 1]
+    name: "Desktop Enrollment (${{ matrix.split }})"
+    runs-on: ubuntu-24.04
+    permissions:
+      contents: read
+      id-token: write
+    env:
+      FIREFOX_CHANNEL: release
+      PYTEST_ARGS: -k FIREFOX_DESKTOP -m desktop_enrollment --reruns 1 --splits 2 --split ${{ matrix.split }} --base-url https://nginx/nimbus/
+      PYTEST_BASE_URL: https://nginx/nimbus/
+    steps:
+      - uses: actions/checkout@v6
+
+      - uses: ./.github/actions/setup-cached-build
+        with:
+          arch: x86_64
+          gcp-project-number: ${{ vars.GCPV2_WORKLOAD_IDENTITY_POOL_PROJECT_NUMBER }}
+
+      - uses: ./.github/actions/run-integration-test
+        with:
+          artifact-name: desktop-enrollment-${{ matrix.split }}-test-report
diff --git a/.github/workflows/integration-desktop-targeting.yml b/.github/workflows/integration-desktop-targeting.yml
new file mode 100644
index 0000000000..646bef105b
--- /dev/null
+++ b/.github/workflows/integration-desktop-targeting.yml
@@ -0,0 +1,48 @@
+name: Desktop Targeting Integration Tests
+
+on:
+  push:
+    branches:
+      - main
+    paths:
+      - "experimenter/**"
+      - "application-services/**"
+      - ".github/actions/run-integration-test/**"
+      - ".github/workflows/integration-desktop-targeting.yml"
+  pull_request:
+    paths:
+      - "experimenter/**"
+      - "application-services/**"
+      - ".github/actions/run-integration-test/**"
+      - ".github/workflows/integration-desktop-targeting.yml"
+  merge_group:
+    types: [checks_requested]
+
+jobs:
+  test:
+    strategy:
+      fail-fast: false
+      matrix:
+        channel: [release, beta, nightly]
+        split: [0, 1]
+    name: "Desktop Targeting (${{ matrix.channel }} ${{ matrix.split }})"
+    runs-on: ubuntu-24.04
+    permissions:
+      contents: read
+      id-token: write
+    env:
+      FIREFOX_CHANNEL: ${{ matrix.channel }}
+      PYTEST_ARGS: -k FIREFOX_DESKTOP -m run_targeting -n 4 --reruns 1 --splits 2 --split ${{ matrix.split }} --base-url https://nginx/nimbus/
+      PYTEST_BASE_URL: https://nginx/nimbus/
+    steps:
+      - uses: actions/checkout@v6
+
+      - uses: ./.github/actions/setup-cached-build
+        with:
+          arch: x86_64
+          gcp-project-number: ${{ vars.GCPV2_WORKLOAD_IDENTITY_POOL_PROJECT_NUMBER }}
+
+      - uses: ./.github/actions/run-integration-test
+        with:
+          make-args: FIREFOX_CHANNEL=${{ matrix.channel }}
+          artifact-name: desktop-targeting-${{ matrix.channel }}-${{ matrix.split }}-test-report
diff --git a/.github/workflows/integration-nimbus-ui.yml b/.github/workflows/integration-nimbus-ui.yml
new file mode 100644
index 0000000000..e7ccf56f2b
--- /dev/null
+++ b/.github/workflows/integration-nimbus-ui.yml
@@ -0,0 +1,42 @@
+name: Nimbus UI Integration Tests
+
+on:
+  push:
+    branches:
+      - main
+    paths:
+      - "experimenter/**"
+      - "application-services/**"
+      - ".github/actions/run-integration-test/**"
+      - ".github/workflows/integration-nimbus-ui.yml"
+  pull_request:
+    paths:
+      - "experimenter/**"
+      - "application-services/**"
+      - ".github/actions/run-integration-test/**"
+      - ".github/workflows/integration-nimbus-ui.yml"
+  merge_group:
+    types: [checks_requested]
+
+jobs:
+  test:
+    name: "Desktop Nimbus UI (Release Firefox)"
+    runs-on: ubuntu-24.04
+    permissions:
+      contents: read
+      id-token: write
+    env:
+      FIREFOX_CHANNEL: release
+      PYTEST_ARGS: -m nimbus_ui -n 4 --reruns 1 --base-url https://nginx/nimbus/
+      PYTEST_BASE_URL: https://nginx/nimbus/
+    steps:
+      - uses: actions/checkout@v6
+
+      - uses: ./.github/actions/setup-cached-build
+        with:
+          arch: x86_64
+          gcp-project-number: ${{ vars.GCPV2_WORKLOAD_IDENTITY_POOL_PROJECT_NUMBER }}
+
+      - uses: ./.github/actions/run-integration-test
+        with:
+          artifact-name: nimbus-ui-test-report
diff --git a/.github/workflows/integration-remote-settings-all.yml b/.github/workflows/integration-remote-settings-all.yml
new file mode 100644
index 0000000000..749020725e
--- /dev/null
+++ b/.github/workflows/integration-remote-settings-all.yml
@@ -0,0 +1,52 @@
+name: Remote Settings All Workflows Integration Tests
+
+on:
+  push:
+    branches:
+      - main
+    paths:
+      - "experimenter/**"
+      - "application-services/**"
+      - ".github/actions/run-integration-test/**"
+      - ".github/workflows/integration-remote-settings-all.yml"
+  pull_request:
+    paths:
+      - "experimenter/**"
+      - "application-services/**"
+      - ".github/actions/run-integration-test/**"
+      - ".github/workflows/integration-remote-settings-all.yml"
+  merge_group:
+    types: [checks_requested]
+
+jobs:
+  test:
+    name: "Remote Settings All Workflows (${{ matrix.name }})"
+    runs-on: ubuntu-24.04
+    permissions:
+      contents: read
+      id-token: write
+    strategy:
+      fail-fast: false
+      matrix:
+        include:
+          - name: Experiments
+            marker: remote_settings_experiments
+          - name: Rollouts
+            marker: remote_settings_rollouts
+          - name: Live Updates
+            marker: remote_settings_live_updates
+    env:
+      FIREFOX_CHANNEL: release
+      PYTEST_ARGS: -k FIREFOX_DESKTOP -m ${{ matrix.marker }} --reruns 1 --base-url https://nginx/nimbus/
+      PYTEST_BASE_URL: https://nginx/nimbus/
+    steps:
+      - uses: actions/checkout@v6
+
+      - uses: ./.github/actions/setup-cached-build
+        with:
+          arch: x86_64
+          gcp-project-number: ${{ vars.GCPV2_WORKLOAD_IDENTITY_POOL_PROJECT_NUMBER }}
+
+      - uses: ./.github/actions/run-integration-test
+        with:
+          artifact-name: remote-settings-all-${{ matrix.marker }}-test-report
diff --git a/.github/workflows/integration-remote-settings-launch.yml b/.github/workflows/integration-remote-settings-launch.yml
new file mode 100644
index 0000000000..1b8bd0acf4
--- /dev/null
+++ b/.github/workflows/integration-remote-settings-launch.yml
@@ -0,0 +1,42 @@
+name: Remote Settings Launch Integration Tests
+
+on:
+  push:
+    branches:
+      - main
+    paths:
+      - "experimenter/**"
+      - "application-services/**"
+      - ".github/actions/run-integration-test/**"
+      - ".github/workflows/integration-remote-settings-launch.yml"
+  pull_request:
+    paths:
+      - "experimenter/**"
+      - "application-services/**"
+      - ".github/actions/run-integration-test/**"
+      - ".github/workflows/integration-remote-settings-launch.yml"
+  merge_group:
+    types: [checks_requested]
+
+jobs:
+  test:
+    name: "Remote Settings Launch (All Applications)"
+    runs-on: ubuntu-24.04
+    permissions:
+      contents: read
+      id-token: write
+    env:
+      FIREFOX_CHANNEL: release
+      PYTEST_ARGS: -m remote_settings_launch --reruns 1 --base-url https://nginx/nimbus/
+      PYTEST_BASE_URL: https://nginx/nimbus/
+    steps:
+      - uses: actions/checkout@v6
+
+      - uses: ./.github/actions/setup-cached-build
+        with:
+          arch: x86_64
+          gcp-project-number: ${{ vars.GCPV2_WORKLOAD_IDENTITY_POOL_PROJECT_NUMBER }}
+
+      - uses: ./.github/actions/run-integration-test
+        with:
+          artifact-name: remote-settings-launch-test-report
diff --git a/Makefile b/Makefile
index 1de8b4888c..15c472b92d 100644
--- a/Makefile
+++ b/Makefile
@@ -127,7 +127,7 @@ build_ui: ssl
 	$(DOCKER_BUILD) --target ui -f experimenter/Dockerfile -t experimenter:ui experimenter/
 
 build_prod: ssl build_megazords
-	$(DOCKER_BUILD) --target deploy -f experimenter/Dockerfile -t experimenter:deploy experimenter/
+	$(DOCKER_BUILD) $(EXPERIMENTER_BUILD_FLAGS) --target deploy -f experimenter/Dockerfile -t experimenter:deploy experimenter/
 
 compose_stop:
 	$(CIRRUS_ENABLE) $(COMPOSE) kill || true
@@ -265,7 +265,7 @@ CIRRUS_PYTHON_TYPECHECK_CREATESTUB = pyright -p . --createstub cirrus
 CIRRUS_GENERATE_DOCS = python cirrus/generate_docs.py
 
 cirrus_build: build_megazords
-	$(CIRRUS_ENABLE) $(DOCKER_BUILD) --target deploy -f cirrus/server/Dockerfile -t cirrus:deploy --build-context=fml=experimenter/experimenter/features/manifests/ cirrus/server/
+	$(CIRRUS_ENABLE) $(DOCKER_BUILD) $(CIRRUS_BUILD_FLAGS) --target deploy -f cirrus/server/Dockerfile -t cirrus:deploy --build-context=fml=experimenter/experimenter/features/manifests/ cirrus/server/
 
 cirrus_build_dev: build_megazords
 	$(CIRRUS_ENABLE) $(DOCKER_BUILD) --target dev -f cirrus/server/Dockerfile -t cirrus:dev --build-context=fml=experimenter/experimenter/features/manifests/ cirrus/server/
diff --git a/experimenter/tests/integration/nimbus/conftest.py b/experimenter/tests/integration/nimbus/conftest.py
index dd808be2f8..796b0e2923 100755
--- a/experimenter/tests/integration/nimbus/conftest.py
+++ b/experimenter/tests/integration/nimbus/conftest.py
@@ -30,6 +30,30 @@
 from nimbus.pages.experimenter.home import HomePage
 from nimbus.utils import helpers
 
+
+def pytest_addoption(parser):
+    parser.addoption(
+        "--split",
+        type=int,
+        default=None,
+        help="This node's split index (0-based)",
+    )
+    parser.addoption(
+        "--splits",
+        type=int,
+        default=None,
+        help="Total number of split nodes",
+    )
+
+
+def pytest_collection_modifyitems(config, items):
+    split = config.getoption("--split")
+    splits = config.getoption("--splits")
+    if split is not None and splits is not None:
+        items.sort(key=lambda item: item.nodeid)
+        items[:] = [item for i, item in enumerate(items) if i % splits == split]
+
+
 APPLICATION_KINTO_REVIEW_PATH = {
     BaseExperimentApplications.FIREFOX_DESKTOP.value: (
         "#/buckets/main-workspace/collections/nimbus-desktop-experiments/simple-review"