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<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"/><title>µ-opioid receptor literature review compilation</title><style>
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</style></head><body><article id="e737c55c-72e4-4f54-a101-06ed8e15929e" class="page sans"><header><img class="page-cover-image" src="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/lipidbilayer2.png" style="object-position:center 10.07%"/><div class="page-header-icon page-header-icon-with-cover"><img class="icon" src="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/membran-protein.png"/></div><h1 class="page-title">µ-opioid receptor literature review compilation</h1></header><div class="page-body"><table class="collection-content"><thead><tr><th><span class="icon property-icon"><svg viewBox="0 0 16 16" style="width:14px;height:14px;display:block;fill:rgba(55, 53, 47, 0.45);flex-shrink:0;-webkit-backface-visibility:hidden" class="typesTitle"><path d="M0.637695 13.1914C1.0957 13.1914 1.32812 13 1.47852 12.5215L2.24414 10.3887H6.14746L6.90625 12.5215C7.05664 13 7.2959 13.1914 7.74707 13.1914C8.22559 13.1914 8.5332 12.9043 8.5332 12.4531C8.5332 12.2891 8.50586 12.1523 8.44434 11.9678L5.41602 3.79199C5.2041 3.21777 4.82129 2.9375 4.19922 2.9375C3.60449 2.9375 3.21484 3.21777 3.0166 3.78516L-0.0322266 12.002C-0.09375 12.1797 -0.121094 12.3232 -0.121094 12.4668C-0.121094 12.918 0.166016 13.1914 0.637695 13.1914ZM2.63379 9.12402L4.17871 4.68066H4.21973L5.76465 9.12402H2.63379ZM12.2793 13.2324C13.3115 13.2324 14.2891 12.6787 14.7129 11.8037H14.7402V12.5762C14.7471 12.9863 15.0273 13.2393 15.4238 13.2393C15.834 13.2393 16.1143 12.9795 16.1143 12.5215V8.00977C16.1143 6.49902 14.9658 5.52148 13.1543 5.52148C11.7666 5.52148 10.6592 6.08887 10.2695 6.99121C10.1943 7.15527 10.1533 7.3125 10.1533 7.46289C10.1533 7.81152 10.4062 8.04395 10.7686 8.04395C11.0215 8.04395 11.2129 7.94824 11.3496 7.73633C11.7529 6.99121 12.2861 6.65625 13.1064 6.65625C14.0977 6.65625 14.6992 7.20996 14.6992 8.1123V8.67285L12.5664 8.7959C10.7686 8.8916 9.77734 9.69824 9.77734 11.0107C9.77734 12.3369 10.8096 13.2324 12.2793 13.2324ZM12.6621 12.1387C11.8008 12.1387 11.2129 11.667 11.2129 10.9561C11.2129 10.2725 11.7598 9.82129 12.7578 9.75977L14.6992 9.62988V10.3203C14.6992 11.3457 13.7969 12.1387 12.6621 12.1387Z"></path></svg></span>Title</th><th><span class="icon property-icon"><svg viewBox="0 0 16 16" style="width:14px;height:14px;display:block;fill:rgba(55, 53, 47, 0.45);flex-shrink:0;-webkit-backface-visibility:hidden" class="typesText"><path d="M1.56738 3.25879H14.4258C14.7676 3.25879 15.0479 2.97852 15.0479 2.63672C15.0479 2.29492 14.7744 2.02148 14.4258 2.02148H1.56738C1.21875 2.02148 0.952148 2.29492 0.952148 2.63672C0.952148 2.97852 1.22559 3.25879 1.56738 3.25879ZM1.56738 6.84082H14.4258C14.7676 6.84082 15.0479 6.56055 15.0479 6.21875C15.0479 5.87695 14.7744 5.60352 14.4258 5.60352H1.56738C1.21875 5.60352 0.952148 5.87695 0.952148 6.21875C0.952148 6.56055 1.22559 6.84082 1.56738 6.84082ZM1.56738 10.4229H14.4258C14.7676 10.4229 15.0479 10.1426 15.0479 9.80078C15.0479 9.45898 14.7744 9.18555 14.4258 9.18555H1.56738C1.21875 9.18555 0.952148 9.45898 0.952148 9.80078C0.952148 10.1426 1.22559 10.4229 1.56738 10.4229ZM1.56738 14.0049H8.75879C9.10059 14.0049 9.38086 13.7246 9.38086 13.3828C9.38086 13.041 9.10742 12.7676 8.75879 12.7676H1.56738C1.21875 12.7676 0.952148 13.041 0.952148 13.3828C0.952148 13.7246 1.22559 14.0049 1.56738 14.0049Z"></path></svg></span>Author</th><th><span class="icon property-icon"><svg viewBox="0 0 16 16" style="width:14px;height:14px;display:block;fill:rgba(55, 53, 47, 0.45);flex-shrink:0;-webkit-backface-visibility:hidden" class="typesNumber"><path d="M2.4834 10.9902H4.33594L3.75488 13.8887C3.74121 13.9639 3.72754 14.0664 3.72754 14.1416C3.72754 14.5381 3.99414 14.7637 4.39746 14.7637C4.81445 14.7637 5.09473 14.5449 5.18359 14.1143L5.80566 10.9902H8.79297L8.21191 13.8887C8.19824 13.9639 8.18457 14.0664 8.18457 14.1416C8.18457 14.5381 8.45117 14.7637 8.85449 14.7637C9.27148 14.7637 9.55176 14.5449 9.63379 14.1143L10.2627 10.9902H12.4502C12.9287 10.9902 13.2432 10.6758 13.2432 10.2109C13.2432 9.8418 12.9902 9.56836 12.6006 9.56836H10.5498L11.2129 6.28711H13.3662C13.8379 6.28711 14.1523 5.96582 14.1523 5.50098C14.1523 5.13184 13.9062 4.8584 13.5098 4.8584H11.5L12.0195 2.27441C12.0264 2.21973 12.0469 2.11035 12.0469 2.01465C12.0469 1.625 11.7666 1.39258 11.3633 1.39258C10.9053 1.39258 10.6797 1.63867 10.5977 2.05566L10.0303 4.8584H7.04297L7.5625 2.27441C7.57617 2.21973 7.58984 2.11035 7.58984 2.01465C7.58984 1.625 7.30957 1.39258 6.91309 1.39258C6.44824 1.39258 6.21582 1.63867 6.13379 2.05566L5.57324 4.8584H3.54297C3.06445 4.8584 2.75 5.18652 2.75 5.65137C2.75 6.03418 3.00293 6.28711 3.39258 6.28711H5.28613L4.62305 9.56836H2.63379C2.15527 9.56836 1.84082 9.89648 1.84082 10.3613C1.84082 10.7373 2.09375 10.9902 2.4834 10.9902ZM6.09277 9.56836L6.75586 6.28711H9.74316L9.08008 9.56836H6.09277Z"></path></svg></span>Year</th><th><span class="icon property-icon"><svg viewBox="0 0 16 16" style="width:14px;height:14px;display:block;fill:rgba(55, 53, 47, 0.45);flex-shrink:0;-webkit-backface-visibility:hidden" class="typesMultipleSelect"><path d="M1.91602 4.83789C2.44238 4.83789 2.87305 4.40723 2.87305 3.87402C2.87305 3.34766 2.44238 2.91699 1.91602 2.91699C1.38281 2.91699 0.952148 3.34766 0.952148 3.87402C0.952148 4.40723 1.38281 4.83789 1.91602 4.83789ZM5.1084 4.52344H14.3984C14.7607 4.52344 15.0479 4.23633 15.0479 3.87402C15.0479 3.51172 14.7607 3.22461 14.3984 3.22461H5.1084C4.74609 3.22461 4.45898 3.51172 4.45898 3.87402C4.45898 4.23633 4.74609 4.52344 5.1084 4.52344ZM1.91602 9.03516C2.44238 9.03516 2.87305 8.60449 2.87305 8.07129C2.87305 7.54492 2.44238 7.11426 1.91602 7.11426C1.38281 7.11426 0.952148 7.54492 0.952148 8.07129C0.952148 8.60449 1.38281 9.03516 1.91602 9.03516ZM5.1084 8.7207H14.3984C14.7607 8.7207 15.0479 8.43359 15.0479 8.07129C15.0479 7.70898 14.7607 7.42188 14.3984 7.42188H5.1084C4.74609 7.42188 4.45898 7.70898 4.45898 8.07129C4.45898 8.43359 4.74609 8.7207 5.1084 8.7207ZM1.91602 13.2324C2.44238 13.2324 2.87305 12.8018 2.87305 12.2686C2.87305 11.7422 2.44238 11.3115 1.91602 11.3115C1.38281 11.3115 0.952148 11.7422 0.952148 12.2686C0.952148 12.8018 1.38281 13.2324 1.91602 13.2324ZM5.1084 12.918H14.3984C14.7607 12.918 15.0479 12.6309 15.0479 12.2686C15.0479 11.9062 14.7607 11.6191 14.3984 11.6191H5.1084C4.74609 11.6191 4.45898 11.9062 4.45898 12.2686C4.45898 12.6309 4.74609 12.918 5.1084 12.918Z"></path></svg></span>Keywords</th><th><span class="icon property-icon"><svg viewBox="0 0 16 16" style="width:14px;height:14px;display:block;fill:rgba(55, 53, 47, 0.45);flex-shrink:0;-webkit-backface-visibility:hidden" class="typesText"><path d="M1.56738 3.25879H14.4258C14.7676 3.25879 15.0479 2.97852 15.0479 2.63672C15.0479 2.29492 14.7744 2.02148 14.4258 2.02148H1.56738C1.21875 2.02148 0.952148 2.29492 0.952148 2.63672C0.952148 2.97852 1.22559 3.25879 1.56738 3.25879ZM1.56738 6.84082H14.4258C14.7676 6.84082 15.0479 6.56055 15.0479 6.21875C15.0479 5.87695 14.7744 5.60352 14.4258 5.60352H1.56738C1.21875 5.60352 0.952148 5.87695 0.952148 6.21875C0.952148 6.56055 1.22559 6.84082 1.56738 6.84082ZM1.56738 10.4229H14.4258C14.7676 10.4229 15.0479 10.1426 15.0479 9.80078C15.0479 9.45898 14.7744 9.18555 14.4258 9.18555H1.56738C1.21875 9.18555 0.952148 9.45898 0.952148 9.80078C0.952148 10.1426 1.22559 10.4229 1.56738 10.4229ZM1.56738 14.0049H8.75879C9.10059 14.0049 9.38086 13.7246 9.38086 13.3828C9.38086 13.041 9.10742 12.7676 8.75879 12.7676H1.56738C1.21875 12.7676 0.952148 13.041 0.952148 13.3828C0.952148 13.7246 1.22559 14.0049 1.56738 14.0049Z"></path></svg></span>Journal</th><th><span class="icon property-icon"><svg viewBox="0 0 16 16" style="width:14px;height:14px;display:block;fill:rgba(55, 53, 47, 0.45);flex-shrink:0;-webkit-backface-visibility:hidden" class="typesFile"><path d="M12.5938 8.44043L7.54883 13.4854C6.26367 14.7773 4.54102 14.6475 3.44043 13.54C2.32617 12.4326 2.20312 10.7168 3.49512 9.4248L10.3926 2.52734C11.1445 1.77539 12.2725 1.63867 13.0039 2.37695C13.7422 3.11523 13.6055 4.22949 12.8535 4.98828L6.08594 11.7627C5.77832 12.0703 5.41602 11.9814 5.2041 11.7764C4.99902 11.5576 4.91016 11.2021 5.21777 10.8877L9.93457 6.1709C10.1738 5.93164 10.1875 5.58301 9.96191 5.35059C9.72949 5.13184 9.38086 5.13867 9.1416 5.37793L4.39746 10.1152C3.67285 10.8535 3.7002 11.9746 4.34961 12.624C5.05371 13.3281 6.12012 13.3145 6.8584 12.5762L13.6602 5.77441C14.9795 4.45508 14.9316 2.71875 13.7764 1.55664C12.6416 0.428711 10.8779 0.34668 9.55176 1.66602L2.61328 8.61816C0.883789 10.3477 1 12.8291 2.57227 14.4014C4.14453 15.9668 6.63281 16.0898 8.3623 14.3672L13.4414 9.28809C13.6738 9.0625 13.667 8.64551 13.4346 8.41992C13.209 8.18066 12.833 8.21484 12.5938 8.44043Z"></path></svg></span>Annotation</th><th><span class="icon property-icon"><svg viewBox="0 0 16 16" style="width:14px;height:14px;display:block;fill:rgba(55, 53, 47, 0.45);flex-shrink:0;-webkit-backface-visibility:hidden" class="typesCheckbox"><path d="M3.85742 14.4561H12.1357C13.6123 14.4561 14.3779 13.6904 14.3779 12.2344V3.91504C14.3779 2.45215 13.6123 1.69336 12.1357 1.69336H3.85742C2.38086 1.69336 1.61523 2.45215 1.61523 3.91504V12.2344C1.61523 13.6973 2.38086 14.4561 3.85742 14.4561ZM3.93945 13.1162C3.30371 13.1162 2.95508 12.7812 2.95508 12.1182V4.02441C2.95508 3.36133 3.30371 3.0332 3.93945 3.0332H12.0537C12.6826 3.0332 13.0381 3.36133 13.0381 4.02441V12.1182C13.0381 12.7812 12.6826 13.1162 12.0537 13.1162H3.93945ZM7.26855 11.3115C7.51465 11.3115 7.72656 11.1885 7.87012 10.9697L10.9258 6.19141C11.0146 6.04785 11.0967 5.88379 11.0967 5.72656C11.0967 5.3916 10.7959 5.16602 10.4746 5.16602C10.2695 5.16602 10.085 5.27539 9.94141 5.50781L7.24121 9.8418L5.96973 8.22168C5.80566 8.00977 5.6416 7.93457 5.43652 7.93457C5.10156 7.93457 4.8418 8.20117 4.8418 8.54297C4.8418 8.70703 4.90332 8.85742 5.01953 9.00098L6.63281 10.9697C6.81738 11.209 7.01562 11.3115 7.26855 11.3115Z"></path></svg></span>!</th><th><span class="icon property-icon"><svg viewBox="0 0 16 16" style="width:14px;height:14px;display:block;fill:rgba(55, 53, 47, 0.45);flex-shrink:0;-webkit-backface-visibility:hidden" class="typesUrl"><path d="M7.69922 10.8945L8.73828 9.84863C7.91797 9.77344 7.34375 9.51367 6.91992 9.08984C5.76465 7.93457 5.76465 6.29395 6.91309 5.14551L9.18262 2.87598C10.3379 1.7207 11.9717 1.7207 13.127 2.87598C14.2891 4.04492 14.2822 5.67188 13.1338 6.82031L11.958 7.99609C12.1768 8.49512 12.2451 9.10352 12.1289 9.62988L14.0908 7.6748C15.7725 6 15.7793 3.62109 14.084 1.92578C12.3887 0.223633 10.0098 0.237305 8.33496 1.91211L5.95605 4.29785C4.28125 5.97266 4.26758 8.35156 5.96289 10.0469C6.36621 10.4434 6.90625 10.7441 7.69922 10.8945ZM8.30078 5.13184L7.26855 6.17773C8.08203 6.25293 8.66309 6.51953 9.08008 6.93652C10.2422 8.09863 10.2422 9.73242 9.08691 10.8809L6.81738 13.1504C5.66211 14.3057 4.03516 14.3057 2.87305 13.1504C1.71094 11.9883 1.71777 10.3545 2.87305 9.20605L4.04199 8.03027C3.83008 7.53125 3.75488 6.92969 3.87109 6.39648L1.91602 8.35156C0.234375 10.0264 0.227539 12.4121 1.92285 14.1074C3.61816 15.8027 5.99707 15.7891 7.67188 14.1143L10.0439 11.7354C11.7256 10.0537 11.7324 7.6748 10.0371 5.98633C9.64062 5.58301 9.10059 5.28223 8.30078 5.13184Z"></path></svg></span>doi</th></tr></thead><tbody><tr id="5a3f3637-9807-4742-855b-55219e2ac95c"><td class="cell-title"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/Structure-based%20Evolution%20of%20G%20protein-biased%20%CE%BC-op%205a3f363798074742855b55219e2ac95c.html"><img class="icon" src="https://cdn-icons-png.flaticon.com/512/4341/4341078.png"/>Structure-based Evolution of G protein-biased
μ-opioid Receptor Agonists</a></td><td class="cell-PkaB">Kobilka, Stanford</td><td class="cell-Rp<u">2022</td><td class="cell-\ZCO"><span class="selected-value select-value-color-blue">Bias Agonism</span><span class="selected-value select-value-color-orange">Experimental</span></td><td class="cell-wPsq">Angew Chem Int Ed Engl</td><td class="cell-;tN]"><span style="margin-right:6px"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/Structure-based%20Evolution%20of%20G%20protein-biased%20%CE%BC-op%205a3f363798074742855b55219e2ac95c/kobilka_angewandte.pdf">kobilka_angewandte.pdf</a></span></td><td class="cell-Vl[N"><div class="checkbox checkbox-on"></div></td><td class="cell-pNtg"><a href="https://doi.org/10.1002/anie.202200269" class="url-value">https://doi.org/10.1002/anie.202200269</a></td></tr><tr id="b7b468f3-219a-469b-9c17-879e7d5c3339"><td class="cell-title"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/Structural%20Assessment%20of%20Agonist%20Efficacy%20in%20the%20%CE%BC%20b7b468f3219a469b9c17879e7d5c3339.html"><img class="icon" src="https://cdn-icons-png.flaticon.com/512/4341/4341078.png"/>Structural Assessment of Agonist Efficacy in the μ-Opioid Receptor: Morphine and Fentanyl Elicit Different Activation Patterns</a></td><td class="cell-PkaB">Giraldo, Barcelona, Spain</td><td class="cell-Rp<u">2021</td><td class="cell-\ZCO"><span class="selected-value select-value-color-green">Ligand Binding</span></td><td class="cell-wPsq">JCIM</td><td class="cell-;tN]"></td><td class="cell-Vl[N"><div class="checkbox checkbox-on"></div></td><td class="cell-pNtg"><a href="https://doi.org/10.1021/acs.jcim.0c00890" class="url-value">https://doi.org/10.1021/acs.jcim.0c00890</a></td></tr><tr id="184525a6-5e20-441c-aa7e-665ccb9d2784"><td class="cell-title"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/TRV130%20partial%20agonism%20and%20capacity%20to%20induce%20anti%20184525a65e20441caa7e665ccb9d2784.html"><img class="icon" src="https://cdn-icons-png.flaticon.com/512/4341/4341078.png"/>TRV130 partial agonism and capacity to induce anti-nociceptive tolerance revealed through reducing available
μ-opioid receptor number</a></td><td class="cell-PkaB">Hales, Dundee, UK</td><td class="cell-Rp<u">2021</td><td class="cell-\ZCO"><span class="selected-value select-value-color-blue">Bias Agonism</span><span class="selected-value select-value-color-orange">Experimental</span></td><td class="cell-wPsq">BPH</td><td class="cell-;tN]"></td><td class="cell-Vl[N"><div class="checkbox checkbox-off"></div></td><td class="cell-pNtg"><a href=" https://doi.org/10.1111/bph.15409" class="url-value"> https://doi.org/10.1111/bph.15409</a></td></tr><tr id="749f34bb-99fa-482b-9a7d-3e8ecde0243a"><td class="cell-title"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/Molecular%20insights%20into%20the%20biased%20signaling%20mecha%20749f34bb99fa482b9a7d3e8ecde0243a.html"><img class="icon" src="https://cdn-icons-png.flaticon.com/512/4341/4341078.png"/>Molecular insights into the biased signaling mechanism of the μ-opioid receptor</a></td><td class="cell-PkaB">Granier, Nice, France</td><td class="cell-Rp<u">2021</td><td class="cell-\ZCO"><span class="selected-value select-value-color-blue">Bias Agonism</span></td><td class="cell-wPsq">Molecular Cell</td><td class="cell-;tN]"><span style="margin-right:6px"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/Molecular%20insights%20into%20the%20biased%20signaling%20mecha%20749f34bb99fa482b9a7d3e8ecde0243a/granier_cell.pdf">granier_cell.pdf</a></span></td><td class="cell-Vl[N"><div class="checkbox checkbox-off"></div></td><td class="cell-pNtg"><a href="https://doi.org/10.1016/j.molcel.2021.07.033" class="url-value">https://doi.org/10.1016/j.molcel.2021.07.033</a></td></tr><tr id="cb9b1361-13c9-48ec-812e-e8c59395206c"><td class="cell-title"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/Structural%20insights%20into%20distinct%20signaling%20profil%20cb9b136113c948ec812ee8c59395206c.html"><img class="icon" src="https://cdn-icons-png.flaticon.com/512/4341/4341078.png"/>Structural insights into distinct signaling profiles of the µOR activated by diverse agonists</a></td><td class="cell-PkaB">Dror, Stanford</td><td class="cell-Rp<u">2021</td><td class="cell-\ZCO"><span class="selected-value select-value-color-pink">PDB paper</span></td><td class="cell-wPsq">Biorxiv</td><td class="cell-;tN]"></td><td class="cell-Vl[N"><div class="checkbox checkbox-off"></div></td><td class="cell-pNtg"><a href="https://doi.org/10.1101/2021.12.07.471645" class="url-value">https://doi.org/10.1101/2021.12.07.471645</a></td></tr><tr id="24a3cb9f-00a2-4c67-a84b-8513399982a6"><td class="cell-title"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/CHARMM%20Force-Field%20Parameters%20for%20Morphine,%20Heroin%2024a3cb9f00a24c67a84b8513399982a6.html"><img class="icon" src="https://cdn-icons-png.flaticon.com/512/4341/4341078.png"/>CHARMM Force-Field Parameters for Morphine, Heroin, and Oliceridine, and Conformational Dynamics of Opioid Drugs</a></td><td class="cell-PkaB">Bondar, Berlin, Germany</td><td class="cell-Rp<u">2021</td><td class="cell-\ZCO"><span class="selected-value select-value-color-red">Force Fields</span></td><td class="cell-wPsq">JCIM</td><td class="cell-;tN]"><span style="margin-right:6px"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/CHARMM%20Force-Field%20Parameters%20for%20Morphine,%20Heroin%2024a3cb9f00a24c67a84b8513399982a6/colina_qm.paper.pdf">qm.paper.pdf</a></span></td><td class="cell-Vl[N"><div class="checkbox checkbox-on"></div></td><td class="cell-pNtg"><a href="https://doi.org/10.1021/acs.jcim.1c00667" class="url-value">https://doi.org/10.1021/acs.jcim.1c00667</a></td></tr><tr id="37bdd194-4b42-4042-9fc6-890f35fac101"><td class="cell-title"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/How%20%CE%BC-opioid%20receptor%20recognizes%20fentanyl%2037bdd1944b4240429fc6890f35fac101.html"><img class="icon" src="https://cdn-icons-png.flaticon.com/512/4341/4341078.png"/>How μ-opioid receptor recognizes fentanyl</a></td><td class="cell-PkaB">Shen, UMD</td><td class="cell-Rp<u">2021</td><td class="cell-\ZCO"><span class="selected-value select-value-color-green">Ligand Binding</span></td><td class="cell-wPsq"><mark class="highlight-red_background">Nature Comm.</mark></td><td class="cell-;tN]"><span style="margin-right:6px"><a 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class="cell-Rp<u">2021</td><td class="cell-\ZCO"><span class="selected-value select-value-color-green">Ligand Binding</span></td><td class="cell-wPsq">JACS Au</td><td class="cell-;tN]"></td><td class="cell-Vl[N"><div class="checkbox checkbox-off"></div></td><td class="cell-pNtg"><a href="https://doi.org/10.1021/jacsau.1c00341" class="url-value">https://doi.org/10.1021/jacsau.1c00341</a></td></tr><tr id="31d10f45-0709-403e-a0aa-04b1e847c41e"><td class="cell-title"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/Mechanism%20of%20%CE%BC-Opioid%20Receptor-Magnesium%20Interacti%2031d10f450709403ea0aa04b1e847c41e.html"><img class="icon" src="https://cdn-icons-png.flaticon.com/512/4341/4341078.png"/>Mechanism of μ-Opioid Receptor-Magnesium Interaction and Positive Allosteric Modulation</a></td><td class="cell-PkaB">Filizola, Mount Sinai</td><td class="cell-Rp<u">2020</td><td class="cell-\ZCO"><span class="selected-value select-value-color-yellow">Allosteric Modulators</span></td><td class="cell-wPsq">Biophysical Journal</td><td class="cell-;tN]"></td><td class="cell-Vl[N"><div class="checkbox checkbox-on"></div></td><td class="cell-pNtg"><a href="https://doi.org/10.1016/j.bpj.2019.10.007" class="url-value">https://doi.org/10.1016/j.bpj.2019.10.007</a></td></tr><tr id="dc2adfa8-7031-4eb5-9c51-0af14b11a8ff"><td class="cell-title"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/Structure%20and%20Dynamics%20of%20GPCRs%20in%20Lipid%20Membranes%20dc2adfa870314eb59c510af14b11a8ff.html"><img class="icon" src="https://cdn-icons-png.flaticon.com/512/4341/4341078.png"/>Structure and Dynamics of GPCRs in Lipid Membranes: Physical Principles and Experimental Approaches</a></td><td class="cell-PkaB">Nietlispach, Cambridge</td><td class="cell-Rp<u">2020</td><td class="cell-\ZCO"><span class="selected-value select-value-color-gray">Cholesterol</span><span class="selected-value select-value-color-brown">Lipids</span><span class="selected-value select-value-color-green">Review</span></td><td class="cell-wPsq">molecules MDPI</td><td class="cell-;tN]"></td><td class="cell-Vl[N"><div class="checkbox checkbox-off"></div></td><td class="cell-pNtg"><a href="https://doi.org/10.3390/molecules25204729" class="url-value">https://doi.org/10.3390/molecules25204729</a></td></tr><tr id="ee8c9fcd-35c2-4fdc-8fcb-f8f2f9cf0ae4"><td class="cell-title"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/Mechanism%20of%20%CE%B2-arrestin%20recruitment%20by%20the%20%C2%B5-opioi%20ee8c9fcd35c24fdc8fcbf8f2f9cf0ae4.html"><img class="icon" src="https://cdn-icons-png.flaticon.com/512/4341/4341078.png"/>Mechanism of β-arrestin recruitment by the µ-opioid G protein-coupled receptor</a></td><td class="cell-PkaB">Goddard, Caltech</td><td class="cell-Rp<u">2020</td><td class="cell-\ZCO"><span class="selected-value select-value-color-blue">Bias Agonism</span></td><td class="cell-wPsq"><mark class="highlight-red_background">PNAS</mark></td><td class="cell-;tN]"><span style="margin-right:6px"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/Mechanism%20of%20%CE%B2-arrestin%20recruitment%20by%20the%20%C2%B5-opioi%20ee8c9fcd35c24fdc8fcbf8f2f9cf0ae4/goddard_pnas_(1).pdf">goddard_pnas (1).pdf</a></span></td><td class="cell-Vl[N"><div class="checkbox checkbox-on"></div></td><td class="cell-pNtg"><a href="https://doi.org/10.1073/pnas.1918264117" class="url-value">https://doi.org/10.1073/pnas.1918264117</a></td></tr><tr id="3ff29652-b016-4707-8502-0304569630e9"><td class="cell-title"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/A%20tetrapeptide%20class%20of%20biased%20analgesics%20from%20an%20%203ff29652b016470785020304569630e9.html"><img class="icon" src="https://cdn-icons-png.flaticon.com/512/4341/4341078.png"/>A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor</a></td><td class="cell-PkaB">Christie, Australia</td><td class="cell-Rp<u">2019</td><td class="cell-\ZCO"><span class="selected-value select-value-color-blue">Bias Agonism</span></td><td class="cell-wPsq">PNAS</td><td class="cell-;tN]"></td><td class="cell-Vl[N"><div class="checkbox checkbox-off"></div></td><td class="cell-pNtg"><a href="https://doi.org/10.1073/pnas.1908662116" class="url-value">https://doi.org/10.1073/pnas.1908662116</a></td></tr><tr id="86bc00a8-e34b-494a-8c25-2009ca9cfa2e"><td class="cell-title"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/In%20silico%20studies%20of%20conformational%20dynamics%20of%20Mu%2086bc00a8e34b494a8c252009ca9cfa2e.html"><img class="icon" src="https://cdn-icons-png.flaticon.com/512/4341/4341078.png"/>In silico studies of conformational dynamics of Mu opioid receptor performed using gaussian accelerated molecular dynamics</a></td><td class="cell-PkaB">Wang, Taiwan</td><td class="cell-Rp<u">2019</td><td class="cell-\ZCO"><span class="selected-value select-value-color-blue">Conformational Changes</span><span class="selected-value select-value-color-brown">Enhanced Sampling</span></td><td class="cell-wPsq">J Biomol Struct Dyn.</td><td class="cell-;tN]"></td><td class="cell-Vl[N"><div class="checkbox checkbox-off"></div></td><td class="cell-pNtg"><a href="https://doi.org/10.1080/07391102.2017.1422025" class="url-value">https://doi.org/10.1080/07391102.2017.1422025</a></td></tr><tr id="c6a6b611-af56-4264-97bd-9e21f9fc299b"><td class="cell-title"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/Diverse%20GPCR%20exhibit%20conserved%20water%20networks%20for%20%20c6a6b611af56426497bd9e21f9fc299b.html"><img class="icon" src="https://cdn-icons-png.flaticon.com/512/4341/4341078.png"/>Diverse GPCR exhibit conserved water networks for stabilization and activation</a></td><td class="cell-PkaB">Dror, Stanford</td><td class="cell-Rp<u">2019</td><td class="cell-\ZCO"><span class="selected-value select-value-color-orange">Waters</span></td><td class="cell-wPsq">PNAS</td><td class="cell-;tN]"><span style="margin-right:6px"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/Diverse%20GPCR%20exhibit%20conserved%20water%20networks%20for%20%20c6a6b611af56426497bd9e21f9fc299b/dror_pnas.pdf">dror_pnas.pdf</a></span></td><td class="cell-Vl[N"><div class="checkbox checkbox-off"></div></td><td class="cell-pNtg"><a href="https://doi.org/10.1073/pnas.1809251116" class="url-value">https://doi.org/10.1073/pnas.1809251116</a></td></tr><tr id="3c816932-f652-4ab6-86c1-47efb891f53a"><td class="cell-title"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/Molecular%20dynamics%20of%20fentanyl%20bound%20to%20%CE%BC-opioid%20r%203c816932f6524ab686c147efb891f53a.html"><img class="icon" src="https://cdn-icons-png.flaticon.com/512/4341/4341078.png"/>Molecular dynamics of fentanyl bound to μ-opioid receptor</a></td><td class="cell-PkaB">Lipinski, Warsaw, Poland</td><td class="cell-Rp<u">2019</td><td class="cell-\ZCO"><span class="selected-value select-value-color-green">Ligand Binding</span></td><td class="cell-wPsq">J Mol Model</td><td class="cell-;tN]"><span style="margin-right:6px"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/Molecular%20dynamics%20of%20fentanyl%20bound%20to%20%CE%BC-opioid%20r%203c816932f6524ab686c147efb891f53a/lipinski_jmm(edited-Smallpdf).pdf">lipinski_jmm(edited-Smallpdf).pdf</a></span></td><td class="cell-Vl[N"><div class="checkbox checkbox-off"></div></td><td class="cell-pNtg"><a href="https://doi.org/10.1007/s00894-019-3999-2" class="url-value">https://doi.org/10.1007/s00894-019-3999-2</a></td></tr><tr id="66fdcb8c-04b3-43ef-9ef3-daa0d8f87a81"><td class="cell-title"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/Kinetic%20and%20thermodynamic%20insights%20into%20sodium%20ion%2066fdcb8c04b343ef9ef3daa0d8f87a81.html"><img class="icon" src="https://cdn-icons-png.flaticon.com/512/4341/4341078.png"/>Kinetic and thermodynamic insights into sodium ion translocation through the μ-opioid receptor from molecular dynamics and machine learning analysis</a></td><td class="cell-PkaB">Filizola, Mount Sinai</td><td class="cell-Rp<u">2019</td><td class="cell-\ZCO"><span class="selected-value select-value-color-yellow">Allosteric Modulators</span></td><td class="cell-wPsq">PLOS</td><td class="cell-;tN]"><span style="margin-right:6px"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/Kinetic%20and%20thermodynamic%20insights%20into%20sodium%20ion%2066fdcb8c04b343ef9ef3daa0d8f87a81/filizola_plos.pdf">filizola_plos.pdf</a></span></td><td class="cell-Vl[N"><div class="checkbox checkbox-on"></div></td><td class="cell-pNtg"><a href="https://doi.org/10.1371/journal.pcbi.1006689" class="url-value">https://doi.org/10.1371/journal.pcbi.1006689</a></td></tr><tr id="a05f87a8-d7f3-4966-b491-c47ec01cd573"><td class="cell-title"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/Drug%20Binding%20Poses%20Relate%20Structure%20with%20Efficacy%20%20a05f87a8d7f34966b491c47ec01cd573.html"><img class="icon" src="https://cdn-icons-png.flaticon.com/512/4341/4341078.png"/>Drug Binding Poses Relate Structure with Efficacy in the μ Opioid Receptor</a></td><td class="cell-PkaB">Sutcliffe, Bristol, UK</td><td class="cell-Rp<u">2017</td><td class="cell-\ZCO"><span class="selected-value select-value-color-red">Activation Mechanism</span><span class="selected-value select-value-color-green">Ligand Binding</span></td><td class="cell-wPsq">JMB</td><td class="cell-;tN]"><span style="margin-right:6px"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/Drug%20Binding%20Poses%20Relate%20Structure%20with%20Efficacy%20%20a05f87a8d7f34966b491c47ec01cd573/sutcliffe_jmb.pdf">sutcliffe_jmb.pdf</a></span></td><td class="cell-Vl[N"><div class="checkbox checkbox-off"></div></td><td class="cell-pNtg"><a href="https://doi.org/10.1016/j.jmb.2017.05.009" class="url-value">https://doi.org/10.1016/j.jmb.2017.05.009</a></td></tr><tr id="afd02a01-2198-4a04-b4af-f6ac97182cdc"><td class="cell-title"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/The%20Mechanism%20of%20Ligand-Induced%20Activation%20or%20Inhi%20afd02a0121984a04b4aff6ac97182cdc.html"><img class="icon" src="https://cdn-icons-png.flaticon.com/512/4341/4341078.png"/>The Mechanism of Ligand-Induced Activation or Inhibition of MOR and KOR</a></td><td class="cell-PkaB">Yuan, Switzerland</td><td class="cell-Rp<u">2015</td><td class="cell-\ZCO"><span class="selected-value select-value-color-red">Activation Mechanism</span><span class="selected-value select-value-color-green">Ligand Binding</span></td><td class="cell-wPsq">Angew Chem Int Ed Engl</td><td class="cell-;tN]"></td><td class="cell-Vl[N"><div class="checkbox checkbox-off"></div></td><td class="cell-pNtg"><a href=" https://doi.org/10.1002/anie.201501742" class="url-value"> https://doi.org/10.1002/anie.201501742</a></td></tr><tr id="92f3d33b-3dac-4228-8445-a164a263415b"><td class="cell-title"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/Structural%20Determinants%20for%20the%20Binding%20of%20Morphin%2092f3d33b3dac42288445a164a263415b.html"><img class="icon" src="https://cdn-icons-png.flaticon.com/512/4341/4341078.png"/>Structural Determinants for the Binding of Morphinan Agonists to the μ-Opioid Receptor</a></td><td class="cell-PkaB">Filizola, Mount Sinai</td><td class="cell-Rp<u">2015</td><td class="cell-\ZCO"><span class="selected-value select-value-color-green">Ligand Binding</span></td><td class="cell-wPsq">PLOS</td><td class="cell-;tN]"></td><td class="cell-Vl[N"><div class="checkbox checkbox-off"></div></td><td class="cell-pNtg"><a href="https://doi.org/10.1371/journal.pone.0135998" class="url-value">https://doi.org/10.1371/journal.pone.0135998</a></td></tr><tr id="59e460d4-b585-445f-ba3f-bc61ae6e4474"><td class="cell-title"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/Activation%20and%20Allosteric%20Modulation%20of%20Human%20%CE%BC%20Op%2059e460d4b585445fba3fbc61ae6e4474.html"><img class="icon" src="https://cdn-icons-png.flaticon.com/512/4341/4341078.png"/>Activation and Allosteric Modulation of Human μ Opioid Receptor in Molecular Dynamics</a></td><td class="cell-PkaB">Bartuzi, Poland</td><td class="cell-Rp<u">2015</td><td class="cell-\ZCO"><span class="selected-value select-value-color-yellow">Allosteric Modulators</span><span class="selected-value select-value-color-green">Ligand Binding</span><span class="selected-value select-value-color-brown">Lipids</span></td><td class="cell-wPsq">JCIM</td><td class="cell-;tN]"><span style="margin-right:6px"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/Activation%20and%20Allosteric%20Modulation%20of%20Human%20%CE%BC%20Op%2059e460d4b585445fba3fbc61ae6e4474/bartuzi_jcim.pdf">bartuzi_jcim.pdf</a></span></td><td class="cell-Vl[N"><div class="checkbox checkbox-off"></div></td><td class="cell-pNtg"><a href="https://doi.org/10.1021/acs.jcim.5b00280" class="url-value">https://doi.org/10.1021/acs.jcim.5b00280</a></td></tr><tr id="809d8b1c-1772-442b-8e81-f5809bfcd785"><td class="cell-title"><a href="%C2%B5-opioid%20receptor%20literature%20review%20compilation%20e737c55c72e44f54a10106ed8e15929e/A%20G%20protein-biased%20ligand%20at%20the%20%CE%BC-opioid%20receptor%20809d8b1c1772442b8e81f5809bfcd785.html"><img class="icon" src="https://cdn-icons-png.flaticon.com/512/4341/4341078.png"/>A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with 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