diff --git a/src/spec-node/configContainer.ts b/src/spec-node/configContainer.ts
index b4e159657..c0b21eb82 100644
--- a/src/spec-node/configContainer.ts
+++ b/src/spec-node/configContainer.ts
@@ -60,7 +60,7 @@ async function resolveWithLocalFolder(params: DockerResolverParameters, parsedAu
 
 	const { dockerCLI, dockerComposeCLI } = params;
 	const { env } = common;
-	const cliParams: DockerCLIParameters = { cliHost, dockerCLI, dockerComposeCLI, env, output, platformInfo: params.platformInfo };
+	const cliParams: DockerCLIParameters = { cliHost, dockerCLI, dockerComposeCLI, env, output, buildPlatformInfo: params.buildPlatformInfo, targetPlatformInfo: params.targetPlatformInfo };
 	await ensureNoDisallowedFeatures(cliParams, config, additionalFeatures, idLabels);
 
 	await runInitializeCommand({ ...params, common: { ...common, output: common.lifecycleHook.output } }, config.initializeCommand, common.lifecycleHook.onDidInput);
diff --git a/src/spec-node/devContainers.ts b/src/spec-node/devContainers.ts
index 8a2e6b042..a856890c6 100644
--- a/src/spec-node/devContainers.ts
+++ b/src/spec-node/devContainers.ts
@@ -172,7 +172,12 @@ export async function createDockerParams(options: ProvisionOptions, disposables:
 		output: common.output,
 	}, dockerPath, dockerComposePath);
 
-	const platformInfo = (() => {
+	const buildPlatformInfo = {
+		os: mapNodeOSToGOOS(cliHost.platform),
+		arch: mapNodeArchitectureToGOARCH(cliHost.arch),
+	};
+
+	const targetPlatformInfo = (() => {
 		if (common.buildxPlatform) {
 			const slash1 = common.buildxPlatform.indexOf('/');
 			const slash2 = common.buildxPlatform.indexOf('/', slash1 + 1);
@@ -204,7 +209,8 @@ export async function createDockerParams(options: ProvisionOptions, disposables:
 		dockerComposeCLI,
 		env: cliHost.env,
 		output,
-		platformInfo
+		buildPlatformInfo,
+		targetPlatformInfo
 	}));
 
 	const dockerEngineVer = await dockerEngineVersion({
@@ -213,7 +219,8 @@ export async function createDockerParams(options: ProvisionOptions, disposables:
 		dockerComposeCLI,
 		env: cliHost.env,
 		output,
-		platformInfo
+		buildPlatformInfo,
+		targetPlatformInfo
 	});	
 
 	return {
@@ -246,7 +253,8 @@ export async function createDockerParams(options: ProvisionOptions, disposables:
 		additionalLabels: options.additionalLabels,
 		buildxOutput: common.buildxOutput,
 		buildxCacheTo: common.buildxCacheTo,
-		platformInfo
+		buildPlatformInfo,
+		targetPlatformInfo
 	};
 }
 
diff --git a/src/spec-node/devContainersSpecCLI.ts b/src/spec-node/devContainersSpecCLI.ts
index fbd501591..18c44136b 100644
--- a/src/spec-node/devContainersSpecCLI.ts
+++ b/src/spec-node/devContainersSpecCLI.ts
@@ -641,7 +641,7 @@ async function doBuild({
 			throw new ContainerError({ description: '--push true cannot be used with --output.' });
 		}
 
-		const buildParams: DockerCLIParameters = { cliHost, dockerCLI: params.dockerCLI, dockerComposeCLI, env, output, platformInfo: params.platformInfo };
+		const buildParams: DockerCLIParameters = { cliHost, dockerCLI: params.dockerCLI, dockerComposeCLI, env, output, buildPlatformInfo: params.buildPlatformInfo, targetPlatformInfo: params.targetPlatformInfo };
 		await ensureNoDisallowedFeatures(buildParams, config, additionalFeatures, undefined);
 
 		// Support multiple use of `--image-name`
@@ -1058,16 +1058,18 @@ async function readConfiguration({
 			env: cliHost.env,
 			output,
 		}, dockerCLI, dockerComposePath || 'docker-compose');
+		const buildPlatformInfo = {
+			os: mapNodeOSToGOOS(cliHost.platform),
+			arch: mapNodeArchitectureToGOARCH(cliHost.arch),
+		};
 		const params: DockerCLIParameters = {
 			cliHost,
 			dockerCLI,
 			dockerComposeCLI,
 			env: cliHost.env,
 			output,
-			platformInfo: {
-				os: mapNodeOSToGOOS(cliHost.platform),
-				arch: mapNodeArchitectureToGOARCH(cliHost.arch),
-			}
+			buildPlatformInfo,
+			targetPlatformInfo: buildPlatformInfo
 		};
 		const { container, idLabels } = await findContainerAndIdLabels(params, containerId, providedIdLabels, workspaceFolder, configPath?.fsPath);
 		if (container) {
diff --git a/src/spec-node/dockerCompose.ts b/src/spec-node/dockerCompose.ts
index 4c20ebd68..8093464cc 100644
--- a/src/spec-node/dockerCompose.ts
+++ b/src/spec-node/dockerCompose.ts
@@ -27,7 +27,7 @@ const serviceLabel = 'com.docker.compose.service';
 export async function openDockerComposeDevContainer(params: DockerResolverParameters, workspace: Workspace, config: SubstitutedConfig<DevContainerFromDockerComposeConfig>, idLabels: string[], additionalFeatures: Record<string, string | boolean | Record<string, string | boolean>>): Promise<ResolverResult> {
 	const { common, dockerCLI, dockerComposeCLI } = params;
 	const { cliHost, env, output } = common;
-	const buildParams: DockerCLIParameters = { cliHost, dockerCLI, dockerComposeCLI, env, output, platformInfo: params.platformInfo };
+	const buildParams: DockerCLIParameters = { cliHost, dockerCLI, dockerComposeCLI, env, output, buildPlatformInfo: params.buildPlatformInfo, targetPlatformInfo: params.targetPlatformInfo };
 	return _openDockerComposeDevContainer(params, buildParams, workspace, config, getRemoteWorkspaceFolder(config.config), idLabels, additionalFeatures);
 }
 
@@ -155,7 +155,7 @@ export async function buildAndExtendDockerCompose(configWithRaw: SubstitutedConf
 	const { cliHost, env, output } = common;
 	const { config } = configWithRaw;
 
-	const cliParams: DockerCLIParameters = { cliHost, dockerCLI, dockerComposeCLI: dockerComposeCLIFunc, env, output, platformInfo: params.platformInfo };
+	const cliParams: DockerCLIParameters = { cliHost, dockerCLI, dockerComposeCLI: dockerComposeCLIFunc, env, output, buildPlatformInfo: params.buildPlatformInfo, targetPlatformInfo: params.targetPlatformInfo };
 	const composeConfig = await readDockerComposeConfig(cliParams, localComposeFiles, envFile);
 	const composeService = composeConfig.services[config.service];
 
diff --git a/src/spec-node/dockerfileUtils.ts b/src/spec-node/dockerfileUtils.ts
index 2a07023aa..b65833fe7 100644
--- a/src/spec-node/dockerfileUtils.ts
+++ b/src/spec-node/dockerfileUtils.ts
@@ -100,7 +100,7 @@ export function findUserStatement(dockerfile: Dockerfile, buildArgs: Record<stri
 	return undefined;
 }
 
-export function findBaseImage(dockerfile: Dockerfile, buildArgs: Record<string, string>, target: string | undefined) {
+export function findBaseImage(dockerfile: Dockerfile, buildArgs: Record<string, string>, target: string | undefined, globalBuildxPlatformArgs: Record<string, string> = {}) {
 	let stage: Stage | undefined = target ? dockerfile.stagesByLabel[target] : dockerfile.stages[dockerfile.stages.length - 1];
 	const seen = new Set<Stage>();
 	while (stage) {
@@ -109,7 +109,7 @@ export function findBaseImage(dockerfile: Dockerfile, buildArgs: Record<string,
 		}
 		seen.add(stage);
 
-		const image = replaceVariables(dockerfile, buildArgs, /* not available in FROM instruction */ {}, stage.from.image, dockerfile.preamble, dockerfile.preamble.instructions.length);
+		const image = replaceVariables(dockerfile, buildArgs, globalBuildxPlatformArgs, stage.from.image, dockerfile.preamble, dockerfile.preamble.instructions.length);
 		const nextStage = dockerfile.stagesByLabel[image];
 		if (!nextStage) {
 			return image;
diff --git a/src/spec-node/imageMetadata.ts b/src/spec-node/imageMetadata.ts
index cb3cc5fa6..85509de80 100644
--- a/src/spec-node/imageMetadata.ts
+++ b/src/spec-node/imageMetadata.ts
@@ -4,6 +4,7 @@
  *--------------------------------------------------------------------------------------------*/
 
 import { ContainerError } from '../spec-common/errors';
+import { PlatformInfo } from '../spec-common/commonUtils';
 import { LifecycleCommand, LifecycleHooksInstallMap } from '../spec-common/injectHeadless';
 import { DevContainerConfig, DevContainerConfigCommand, DevContainerFromDockerComposeConfig, DevContainerFromDockerfileConfig, DevContainerFromImageConfig, getDockerComposeFilePaths, getDockerfilePath, HostGPURequirements, HostRequirements, isDockerFileConfig, PortAttributes, UserEnvProbe } from '../spec-configuration/configuration';
 import { Feature, FeaturesConfig, Mount, parseMount, SchemaFeatureLifecycleHooks } from '../spec-configuration/containerFeaturesConfiguration';
@@ -349,7 +350,7 @@ export async function getImageBuildInfo(params: DockerResolverParameters | Docke
 		const cwdEnvFile = cliHost.path.join(cliHost.cwd, '.env');
 		const envFile = Array.isArray(config.dockerComposeFile) && config.dockerComposeFile.length === 0 && await cliHost.isFile(cwdEnvFile) ? cwdEnvFile : undefined;
 		const composeFiles = await getDockerComposeFilePaths(cliHost, config, cliHost.env, cliHost.cwd);
-		const buildParams: DockerCLIParameters = { cliHost, dockerCLI, dockerComposeCLI, env: cliHost.env, output, platformInfo: params.platformInfo };
+		const buildParams: DockerCLIParameters = { cliHost, dockerCLI, dockerComposeCLI, env: cliHost.env, output, buildPlatformInfo: params.buildPlatformInfo, targetPlatformInfo: params.targetPlatformInfo };
 
 		const composeConfig = await readDockerComposeConfig(buildParams, composeFiles, envFile);
 		const services = Object.keys(composeConfig.services || {});
@@ -394,18 +395,40 @@ export async function getImageBuildInfoFromImage(params: DockerResolverParameter
 export async function getImageBuildInfoFromDockerfile(params: DockerResolverParameters | DockerCLIParameters, dockerfile: string, dockerBuildArgs: Record<string, string>, targetStage: string | undefined, substitute: SubstituteConfig) {
 	const { output } = 'output' in params ? params : params.common;
 	const omitSyntaxDirective = 'common' in params ? !!params.common.omitSyntaxDirective : false;
-	return internalGetImageBuildInfoFromDockerfile(imageName => inspectDockerImage(params, imageName, true), dockerfile, dockerBuildArgs, targetStage, substitute, output, omitSyntaxDirective);
+	return internalGetImageBuildInfoFromDockerfile(imageName => inspectDockerImage(params, imageName, true), dockerfile, dockerBuildArgs, targetStage, substitute, output, omitSyntaxDirective, params.buildPlatformInfo, params.targetPlatformInfo);
 }
 
-export async function internalGetImageBuildInfoFromDockerfile(inspectDockerImage: (imageName: string) => Promise<ImageDetails>, dockerfileText: string, dockerBuildArgs: Record<string, string>, targetStage: string | undefined, substitute: SubstituteConfig, output: Log, omitSyntaxDirective: boolean): Promise<ImageBuildInfo> {
+export async function internalGetImageBuildInfoFromDockerfile(inspectDockerImage: (imageName: string) => Promise<ImageDetails>, dockerfileText: string, dockerBuildArgs: Record<string, string>, targetStage: string | undefined, substitute: SubstituteConfig, output: Log, omitSyntaxDirective: boolean, buildPlatform: PlatformInfo, targetPlatform: PlatformInfo): Promise<ImageBuildInfo> {
 	const dockerfile = extractDockerfile(dockerfileText);
 	if (dockerfile.preamble.directives.syntax && omitSyntaxDirective) {
 		output.write(`Omitting syntax directive '${dockerfile.preamble.directives.syntax}' from Dockerfile.`, LogLevel.Trace);
 		delete dockerfile.preamble.directives.syntax;
 	}
-	const baseImage = findBaseImage(dockerfile, dockerBuildArgs, targetStage);
+	// https://github.com/moby/buildkit/blob/master/frontend/dockerfile/docs/reference.md#automatic-platform-args-in-the-global-scope
+	const globalBuildxPlatformArgs = {
+		// platform of the node performing the build.
+		BUILDPLATFORM: [buildPlatform.os, buildPlatform.arch, buildPlatform.variant].filter(Boolean).join("/"),
+		// OS component of BUILDPLATFORM
+		BUILDOS: buildPlatform.os,
+		// architecture component of BUILDPLATFORM
+		BUILDARCH: buildPlatform.arch,
+		// variant component of BUILDPLATFORM
+		BUILDVARIANT: buildPlatform.variant ?? "",
+		// platform of the build result. Eg linux/amd64, linux/arm/v7, windows/amd64.
+		TARGETPLATFORM: [targetPlatform.os, targetPlatform.arch, targetPlatform.variant].filter(Boolean).join("/"),
+		// OS component of TARGETPLATFORM
+		TARGETOS: targetPlatform.os,
+		// architecture component of TARGETPLATFORM
+		TARGETARCH: targetPlatform.arch,
+		// variant component of TARGETPLATFORM
+		TARGETVARIANT: targetPlatform.variant ?? "",
+	};
+	const baseImage = findBaseImage(dockerfile, dockerBuildArgs, targetStage, globalBuildxPlatformArgs);
 	const imageDetails = baseImage && await inspectDockerImage(baseImage) || undefined;
-	const dockerfileUser = findUserStatement(dockerfile, dockerBuildArgs, envListToObj(imageDetails?.Config.Env), targetStage);
+	const dockerfileUser = findUserStatement(dockerfile, dockerBuildArgs, {
+		...envListToObj(imageDetails?.Config.Env),
+		...globalBuildxPlatformArgs,
+	}, targetStage);
 	const user = dockerfileUser || imageDetails?.Config.User || 'root';
 	const metadata = imageDetails ? getImageMetadata(imageDetails, substitute, output) : { config: [], raw: [], substitute };
 	return {
diff --git a/src/spec-node/upgradeCommand.ts b/src/spec-node/upgradeCommand.ts
index dfdf8e7e7..51410de07 100644
--- a/src/spec-node/upgradeCommand.ts
+++ b/src/spec-node/upgradeCommand.ts
@@ -86,16 +86,18 @@ async function featuresUpgrade({
 			env: cliHost.env,
 			output,
 		}, dockerPath, dockerComposePath);
+		const buildPlatformInfo = {
+			os: mapNodeOSToGOOS(cliHost.platform),
+			arch: mapNodeArchitectureToGOARCH(cliHost.arch),
+		};
 		const dockerParams: DockerCLIParameters = {
 			cliHost,
 			dockerCLI: dockerPath,
 			dockerComposeCLI,
 			env: cliHost.env,
 			output,
-			platformInfo: {
-				os: mapNodeOSToGOOS(cliHost.platform),
-				arch: mapNodeArchitectureToGOARCH(cliHost.arch),
-			}
+			buildPlatformInfo,
+			targetPlatformInfo: buildPlatformInfo,
 		};
 
 		const workspace = workspaceFromPath(cliHost.path, workspaceFolder);
diff --git a/src/spec-node/utils.ts b/src/spec-node/utils.ts
index bdf5289f0..74817d1a0 100644
--- a/src/spec-node/utils.ts
+++ b/src/spec-node/utils.ts
@@ -134,7 +134,8 @@ export interface DockerResolverParameters {
 	additionalLabels: string[];
 	buildxOutput: string | undefined;
 	buildxCacheTo: string | undefined;
-	platformInfo: PlatformInfo;
+	buildPlatformInfo: PlatformInfo;
+	targetPlatformInfo: PlatformInfo;
 }
 
 export interface ResolverResult {
@@ -250,7 +251,7 @@ export async function inspectDockerImage(params: DockerResolverParameters | Dock
 			throw inspectErr;
 		}
 		try {
-			return await inspectImageInRegistry(output, params.platformInfo, imageName);
+			return await inspectImageInRegistry(output, params.targetPlatformInfo, imageName);
 		} catch (inspectErr2) {
 			output.write(`Error fetching image details: ${inspectErr2?.message}`, LogLevel.Info);
 		}
diff --git a/src/spec-shutdown/dockerUtils.ts b/src/spec-shutdown/dockerUtils.ts
index 3aa4d8166..9f0bce850 100644
--- a/src/spec-shutdown/dockerUtils.ts
+++ b/src/spec-shutdown/dockerUtils.ts
@@ -52,7 +52,8 @@ export interface DockerCLIParameters {
 	dockerComposeCLI: () => Promise<DockerComposeCLI>;
 	env: NodeJS.ProcessEnv;
 	output: Log;
-	platformInfo: PlatformInfo;
+	buildPlatformInfo: PlatformInfo;
+	targetPlatformInfo: PlatformInfo;
 }
 
 export interface PartialExecParameters {
diff --git a/src/test/dockerfileUtils.test.ts b/src/test/dockerfileUtils.test.ts
index 979375b91..4fe292168 100644
--- a/src/test/dockerfileUtils.test.ts
+++ b/src/test/dockerfileUtils.test.ts
@@ -178,7 +178,7 @@ FROM ubuntu:latest as dev
         const info = await internalGetImageBuildInfoFromDockerfile(async (imageName) => {
             assert.strictEqual(imageName, 'ubuntu:latest');
             return details;
-        }, dockerfile, {}, undefined, testSubstitute, nullLog, false);
+        }, dockerfile, {}, undefined, testSubstitute, nullLog, false, {} as any, {} as any);
         assert.strictEqual(info.user, 'imageUser');
         assert.strictEqual(info.metadata.config.length, 1);
         assert.strictEqual(info.metadata.config[0].id, 'testid-substituted');
@@ -206,11 +206,44 @@ USER dockerfileUserB
         const info = await internalGetImageBuildInfoFromDockerfile(async (imageName) => {
             assert.strictEqual(imageName, 'ubuntu:latest');
             return details;
-        }, dockerfile, {}, undefined, testSubstitute, nullLog, false);
+        }, dockerfile, {}, undefined, testSubstitute, nullLog, false, {} as any, {} as any);
         assert.strictEqual(info.user, 'dockerfileUserB');
         assert.strictEqual(info.metadata.config.length, 0);
         assert.strictEqual(info.metadata.raw.length, 0);
     });
+
+    it('for a USER in a multiarch image', async () => {
+        const dockerfile = `
+FROM ubuntu:latest as base-amd64
+USER amd64_user
+
+FROM ubuntu:latest as base-arm64
+USER arm64_user
+
+FROM base-\${TARGETARCH}
+
+ARG TARGETARCH
+`;
+        const details: ImageDetails = {
+            Id: '123',
+            Config: {
+                User: 'imageUser',
+                Env: null,
+                Labels: null,
+                Entrypoint: null,
+                Cmd: null
+            },
+						Os: 'linux',
+						Architecture: 'amd64'
+        };
+        const info = await internalGetImageBuildInfoFromDockerfile(async (imageName) => {
+            assert.strictEqual(imageName, 'ubuntu:latest');
+            return details;
+        }, dockerfile, {}, undefined, testSubstitute, nullLog, false, {} as any, { os: 'linux', arch: 'amd64' });
+        assert.strictEqual(info.user, 'amd64_user');
+        assert.strictEqual(info.metadata.config.length, 0);
+        assert.strictEqual(info.metadata.raw.length, 0);
+    });
 });
 
 describe('findBaseImage', () => {
diff --git a/src/test/testUtils.ts b/src/test/testUtils.ts
index cd48c5359..22597dce2 100644
--- a/src/test/testUtils.ts
+++ b/src/test/testUtils.ts
@@ -154,16 +154,18 @@ export async function createCLIParams(hostPath: string) {
 		env: cliHost.env,
 		output,
 	}, 'docker', 'docker-compose');
+	const buildPlatformInfo = {
+		os: mapNodeOSToGOOS(cliHost.platform),
+		arch: mapNodeArchitectureToGOARCH(cliHost.arch),
+	};
 	const cliParams: DockerCLIParameters = {
 		cliHost,
 		dockerCLI: 'docker',
 		dockerComposeCLI,
 		env: {},
 		output,
-		platformInfo: {
-			os: mapNodeOSToGOOS(cliHost.platform),
-			arch: mapNodeArchitectureToGOARCH(cliHost.arch),
-		}
+		buildPlatformInfo,
+		targetPlatformInfo: buildPlatformInfo,
 };
 	return cliParams;
 }